trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline

J Med Chem. 1991 Jan;34(1):455-7. doi: 10.1021/jm00105a068.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cerebral Cortex / metabolism
  • Guinea Pigs
  • Hydroxyproline
  • Indicators and Reagents
  • Methionine*
  • Molecular Structure
  • Pancreas / metabolism
  • Proline / analogs & derivatives*
  • Proline / chemical synthesis
  • Receptors, Cholecystokinin / metabolism*
  • Structure-Activity Relationship
  • Tetragastrin / analogs & derivatives*
  • Tetragastrin / chemical synthesis*
  • Tetragastrin / metabolism
  • Tetragastrin / pharmacology

Substances

  • Indicators and Reagents
  • Receptors, Cholecystokinin
  • Tetragastrin
  • 3-propylproline
  • 3-allylproline
  • Proline
  • Methionine
  • Hydroxyproline